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Article

Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562.

British journal of haematology - 1 Jul 1999

Dumontet C, Fabianowska-Majewska K, Mantincic D, Callet Bauchu E, Tigaud I, Gandhi V, Lepoivre M, Peters G J, Rolland M O, Wyczechowska D, Fang X, Gazzo S, Voorn D A, Vanier-Viornery A, MacKey J

Abstract excerpt

Resistant variants of the human leukaemic line K562 were developed using selection with the deoxynucleoside analogues cytosine arabinoside, 2-chlorodeoxyadenosine, fludarabine and gemcitabine. The resistant lines displayed a high degree of cross resistance to all deoxynucleoside analogues, with little or no cross resistance to other agents. There was a profound accumulation defect of all nucleoside analogues in...

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Identifiers

PMID: 10444166
DOI: 10.1046/j.1365-2141.1999.01509.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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