Article
Common genetic variation in CYP1B1 is associated with concentrations of T₄, FT₃ and FT₄ in the sera of polycystic ovary syndrome patients.
Molecular biology reports - 1 Apr 2013
Zou Shien, Sang Qing, Wang Huan, Feng Ruizhi, Li Qiaoli, Zhao Xinzhi, Xing Qinghe, Jin Li, He Lin, Wang Lei
Abstract excerpt
CYP1B1 encodes an estrogen enzyme that oxidizes 17β-estradiol to 4-hydroxyestradiol. The evidence demonstrates there may be a relationship between CYP1B1 and thyroid function. To date, no study has evaluated if genetic polymorphisms that regulate concentrations of serum FT3 and FT4 contribute to Polycyctic Ovary Syndrome (PCOS). To identify polymorphisms in the CYP1B1 locus associated with PCOS, we genotyped...
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