Article
Genetic polymorphism CYP17 rs2486758 and metabolic risk factors predict daily salivary 17β-estradiol concentration in healthy premenopausal Norwegian women. The EBBA-I study.
The Journal of clinical endocrinology and metabolism - 1 May 2012
Iversen Anita, Thune Inger, McTiernan Anne, Makar Karen W, Wilsgaard Tom, Ellison Peter T, Jasienska Grazyna, Flote Vidar, Poole Elizabeth M, Furberg Anne-Sofie
Abstract excerpt
CONTEXT: The relationship between low-penetrance genes, metabolic risk factors, and levels of endogenous 17β-estradiol and progesterone, which play a role in breast cancer risk, remains unclear. OBJECTIVE: The aim of this study was to determine whether common polymorphisms in CYP17, in combination with metabolic risk factors (individually or clustered), alter salivary concentrations of free biologically active...
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