Article
A family-based association study identified CYP17 as a candidate gene for obesity susceptibility in Caucasians.
Genetics and molecular research : GMR - 6 Aug 2012
Yan H, Guo Y, Yang T-L, Zhao L-J, Deng H-W
Abstract excerpt
The cytochrome P450c17α gene (CYP17) encodes a key biosynthesis enzyme of estrogen, which is critical in regulating adipogenesis and adipocyte development in humans. We therefore hypothesized that CYP17 is a candidate gene for predicting obesity. In order to test this hypothesis, we performed a family-based association test to investigate the relationship between the CYP17 gene and obesity phenotypes in a...
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