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Article

CYP4A11 variant is associated with high-density lipoprotein cholesterol in women.

The pharmacogenomics journal - 1 Feb 2013

White C C, Feng Q, Cupples L A, Gainer J V, Dawson E P, Wilke R A, Brown N J

Abstract excerpt

The ω-hydroxylase CYP4A11 catalyzes the transformation of epoxyeicosatrienoic acids (EETs) to ω-hydroxylated EETs, endogenous peroxisome proliferator-activated receptor-α (PPARα) agonists. PPARα activation increases high-density lipoprotein cholesterol (HDL-C). A cytosine-for-thymidine (T8590C) variant of CYP4A11 encodes for an ω-hydroxylase with reduced activity. This study examined the relationship between...

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Identifiers

PMID: 21912424
DOI: 10.1038/tpj.2011.40
PMCID: PMC3380161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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