Article
Trp28Arg/Ile35Thr LHB gene variants are associated with elevated testosterone levels in women with polycystic ovary syndrome.
Gene - 15 Oct 2014
Batista Mariani Carla Prudente, Duarte Eliane de Fatima, Borba Michele Delarmelina dos Reis, Zingler Emilie, Mangussi-Gomes João, dos Santos Beatriz Taynara Araújo, de Moraes Olivia Laquis, Hayashida Sylvia Asaka Yamashita, Baracat Edmund C, da Rocha Neves Francisco de Assis, Maciel Gustavo Arantes Rosa, Bachega Tania Aparecida Sartori Sanchez, Barra Gustavo Barcelos, Lofrano-Porto Adriana
Abstract excerpt
INTRODUCTION: Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder, of multifactorial etiology, which affects 6-10% of women of reproductive age. It is considered the leading cause of anovulatory infertility, menstrual disorders and hyperandrogenism in this population. The genetic basis of PCOS is still largely unknown despite significant family clustering; determining its mode of inheritance is...
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