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Article

Common genetic variation in the ABCB1 gene is associated with the cholesterol-lowering effect of simvastatin in males.

Pharmacogenomics - 1 Nov 2009

Becker Matthijs L, Visser Loes E, van Schaik Ron H N, Hofman Albert, Uitterlinden André G, Stricker Bruno H Ch

Abstract excerpt

AIMS: The cholesterol-lowering drug simvastatin is a substrate for P-glycoprotein (P-gp). P-gp, encoded by ABCB1, is an efflux transporter and genetic variation in ABCB1 is associated with drug levels and response. We examined the Rotterdam Study, which is a population-based cohort study of people aged 55 years and older, to see whether the C1236T, G2677T/A and C3435T polymorphisms and haplotypes in the ABCB1...

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Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

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Source

Identifiers

PMID: 19891551
DOI: 10.2217/pgs.09.105

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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