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Regulating Cytokine Function Enhances Safety and Activity of Genetic Cancer Therapies

1 Jan 2013

Abstract excerpt

Genetic therapies, including transfected immune cells and viral vectors, continue to show clinical responses as systemically deliverable and targeted therapeutics, with the first such approaches having been approved for cancer treatment. The majority of these employ cytokine transgenes. However, expression of cytokines early after systemic delivery can result in increased toxicity and nonspecific induction of the...

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PMID: 23281444
DOI: 10.1038/mt.2012.225

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