Article

Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies

2024-11-28

Abstract excerpt

Effective cancer therapies must address the tumor microenvironment (TME), a complex network of tumor cells and stromal components, including endothelial, immune, and mesenchymal cells. Durable outcomes require targeting both tumor cells and the TME while minimizing systemic toxicity. Interleukin-2 (IL-2)-based therapies have shown efficacy in cancers such as metastatic melanoma and renal carcinoma but are limited...

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Literature Corpus work: 8c89ae1b-38e3-515e-ab1a-9b8bdc15ddec
DOI: 10.20944/preprints202411.2133.v1

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