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Article

Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors.

Frontiers in immunology - 1 Jan 2021

Ghahri-Saremi Navid, Akbari Behnia, Soltantoyeh Tahereh, Hadjati Jamshid, Ghassemi Saba, Mirzaei Hamid Reza

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy has shown unprecedented success in treating advanced hematological malignancies. Its effectiveness in solid tumors has been limited due to heterogeneous antigen expression, a suppressive tumor microenvironment, suboptimal trafficking to the tumor site and poor CAR T cell persistence. Several approaches have been developed to overcome these obstacles through various...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34721401
DOI: 10.3389/fimmu.2021.738456
PMCID: PMC8552010

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