Article

Optimization of velocity receptor transduction in CAR T cells

2025-10-06

Abstract excerpt

<h4>ABSTRACT</h4> Limited infiltration capacity significantly limits the effectiveness of chimeric antigen receptor (CAR) T cells for solid tumors. We have recently developed a large family of highly modular synthetic cytokine receptors termed velocity receptors (VRs), capable of binding key inflammatory cytokines, such as IL5, IL8, and TNFα, which drive CAR T cells into an elevated motility state. These new CAR...

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Literature Corpus work: 230d06f7-88b6-5a55-a816-c192cb16896f
DOI: 10.1101/2025.10.05.680548

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