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In vivo gene immunotherapy for cancer

9 Nov 2022

Abstract excerpt

Cancer is becoming increasingly understood not only as a disease of pathological cells but also as one of immune hypofunction. The heterogenous and patient-specific nature of cancer further underscores the need for personalized cellular therapies, which are currently produced ex vivo. Gene-modulating approaches, such as therapeutic RNAs and improved viral vectors, now bring us closer toward strategies for...

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PMID: 36350990
DOI: 10.1126/scitranslmed.abo3603

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