Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium.

doi:10.1186/1471-230X-13-1

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Article

Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium.

BMC gastroenterology - 2 Jan 2013

Nomura Tomoe, Tahara Tomomitsu, Shiroeda Hisakazu, Minato Takahiro, Matsue Yasuhiro, Hayashi Ranji, Matsunaga Kazuhiro, Otsuka Toshimi, Nakamura Masakatsu, Toshikuni Nobuyuki, Shibata Tomoyuki, Arisawa Tomiyasu

Abstract excerpt

BACKGROUND: Aberrant methylation patterns in CpG island are known to be influential in gene silencing. Histamine plays important physiological roles in the upper gastrointestinal tract and acts via the H2 receptor. We report an investigation into the effect of HRH2 promoter polymorphism (rs2607474 G > A) on the methylation of DAPK and CDH1. METHODS: Non cancerous gastric mucosa samples were obtained from 115...

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Identifiers

PMID: 23280118
DOI: 10.1186/1471-230X-13-1
PMCID: PMC3583698

Genes

CDH1
HRH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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