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Article

NFKB1 polymorphism is associated with age-related gene methylation in Helicobacter pylori-infected subjects.

International journal of molecular medicine - 1 Aug 2012

Arisawa Tomiyasu, Tahara Tomomitsu, Shiroeda Hisakazu, Yamada Hideto, Nomura Tomoe, Hayashi Ranji, Saito Takashi, Fukuyama Tomoki, Otsuka Toshimi, Nakamura Masakatsu, Toshikuni Nobuyuki, Tsuchishima Mutsumi, Shibata Tomoyuki

Abstract excerpt

CpG island aberrant methylation is shown to be an important mechanism in gene silencing. The important role of NF-κB in the inflammatory response to H. pylori colonization has been indicated. We investigated the influence of NFKB1 polymorphisms, -94 ins/del (rs28362491) and -449 C>G (rs72696119), on the aberrant gene methylation under H. pylori infection. Gastric mucosal samples were obtained from sub-subjects...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22614238
DOI: 10.3892/ijmm.2012.1004

Genes

NFKB1
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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