Article

Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease

2023-06-27

Abstract excerpt

<h4>Background: </h4> E-cadherin, a major actor of cell adhesion in the intestinal barrier, is encoded by the CDH1 gene and associated with susceptibility to Crohn's Disease (CD) and colorectal cancer. Since epigenetic mechanisms are suspected to contribute to the pathogenesis of CD, we studied the methylation of the CpG island (CGI) located in the CDH1 promoter and of 4 CpGs in the 7th enhancer in inflamed ileal...

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Literature Corpus work: f1f38206-03f4-53c0-bb6c-f4e2ebaf0912
DOI: 10.21203/rs.3.rs-3084565/v1

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