Effects of -1018G>A polymorphism of HRH2 (rs2607474) on the severity of gastric mucosal atrophy.

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Article

Effects of -1018G>A polymorphism of HRH2 (rs2607474) on the severity of gastric mucosal atrophy.

Journal of gastrointestinal and liver diseases : JGLD - 1 Jun 2012

Yamada Hideto, Tahara Tomomitsu, Shiroeda Hisakazu, Hayashi Ranji, Saito Takashi, Nakamura Masakatsu, Tsuchishima Mutsumi, Tsutsumi Mikihiro, Shibata Tomoyuki, Arisawa Tomiyasu

Abstract excerpt

BACKGROUND AND AIM: Histamine plays important physiological roles in upper gastrointestinal tract and acts via the H2 receptor. A polymorphism -1018 G>A (rs2067474) was identified in an enhancer element of the HRH2 promoter. We attempted to clarify the associations of this polymorphism with the progression of gastric mucosal atrophy. METHODS: Gastric mucosa samples were obtained from 398 subjects with no...

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PMID: 22720301

Genes

HRH2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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