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Article

MTHFR 677T carrier influences the methylation status of H. pylori-infected gastric mucosa in older subjects.

Digestive diseases and sciences - 1 Nov 2009

Tahara Tomomitsu, Shibata Tomoyuki, Nakamura Masakatsu, Yamashita Hiromi, Yoshioka Daisuke, Okubo Masaaki, Maruyama Naoko, Kamano Toshiaki, Kamiya Yoshio, Fujita Hiroshi, Nakagawa Yoshihito, Nagasaka Mitsuo, Iwata Masami, Takahama Kazuya, Watanabe Makoto, Hirata Ichiro, Arisawa Tomiyasu

Abstract excerpt

DNA methylation is one of the major events in the early process of gastric carcinogenesis and it also occurs in non-neoplastic gastric mucosa. MTHFR plays a central role in biotransformation of folate to form S-adenosylmethionine, the universal methyl donor in cells and affects DNA methylation st...

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Source

Identifiers

PMID: 19082889
DOI: 10.1007/s10620-008-0624-0

Genes

MTHFR
CDH1
DAP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19082889-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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