Article
Constitutive differences in gene expression profiles parallel genetic patterns of susceptibility to tuberculosis in mice.
Infection and immunity - 1 Jun 2006
Orlova Marianna O, Majorov Konstantin B, Lyadova Irina V, Eruslanov Eugenii B, M'lan Cyr E, Greenwood Celia M T, Schurr Erwin, Apt Alexander S
Abstract excerpt
Interstitial lung macrophages from tuberculosis-susceptible I/St and tuberculosis-resistant A/Sn mice demonstrated significant constitutive differences in gene expression levels, whereas in vitro infection of these cells with Mycobacterium tuberculosis had only a modulatory impact on gene expression. We conclude that intrinsic gene expression profiles are an important determinant of tuberculosis pathogenesis in mice.
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