Article
Comparative analysis of T lymphocytes recovered from the lungs of mice genetically susceptible, resistant, and hyperresistant to Mycobacterium tuberculosis-triggered disease.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2000
Lyadova I V, Eruslanov E B, Khaidukov S V, Yeremeev V V, Majorov K B, Pichugin A V, Nikonenko B V, Kondratieva T K, Apt A S
Abstract excerpt
Genetic control of susceptibility to tuberculosis (TB) is being intensively studied, and immune responses to mycobacteria are considerably well characterized. However, it remains largely unknown which parameters of response distinguish resistant and susceptible TB phenotypes. Mice of I/St and A/Sn inbred strains and (A/Sn x I/St)F(1) hybrids were previously categorized as, respectively, susceptible, resistant,...
Topics
- Animals
- Antigens, Bacterial
- Cell Membrane
- Cell Separation
- Crosses, Genetic
- Cytokines
- Female
- Genetic Predisposition to Disease
- Immunity, Innate
- Immunophenotyping
- Lung
- Lymphocyte Activation
- Macrophage Activation