Article
Resistance and susceptibility to tuberculosis analysed at the transcriptome level: lessons from mouse macrophages.
Tuberculosis (Edinburgh, Scotland) - 1 Jan 2004
Keller Christine, Lauber Joerg, Blumenthal Antje, Buer Jan, Ehlers Stefan
Abstract excerpt
Gene expression patterns associated with resistance and susceptibility to tuberculosis (TB) were investigated at the macrophage level in the well-defined mouse model of infection. Oligonucleotide microarrays were used to analyse the regulation of gene expression in murine bone marrow-derived macrophages infected with Mycobacterium tuberculosis. Four mouse strains, known to differ in terms of growth permissiveness...
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