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Article

In vivo regulation of E2F1 by Polycomb group genes in Drosophila.

G3 (Bethesda, Md.) - 1 Dec 2012

Ji Jun-Yuan, Miles Wayne O, Korenjak Michael, Zheng Yani, Dyson Nicholas J

Abstract excerpt

The E2F transcription factors are important regulators of the cell cycle whose function is commonly misregulated in cancer. To identify novel regulators of E2F1 activity in vivo, we used Drosophila to conduct genetic screens. For this, we generated transgenic lines that allow the tissue-specific depletion of dE2F1 by RNAi. Expression of these transgenes using Gal4 drivers in the eyes and wings generated reliable...

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Identifiers

PMID: 23275887
DOI: 10.1534/g3.112.004333
PMCID: PMC3516486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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