Article
A genetic screen for modifiers of E2F in Drosophila melanogaster.
Genetics - 1 Sept 1999
Staehling-Hampton K, Ciampa P J, Brook A, Dyson N
Abstract excerpt
The activity of the E2F transcription factor is regulated in part by pRB, the protein product of the retinoblastoma tumor suppressor gene. Studies of tumor cells show that the p16(ink4a)/cdk4/cyclin D/pRB pathway is mutated in most forms of cancer, suggesting that the deregulation of E2F, and hence the cell cycle, is a common event in tumorigenesis. Extragenic mutations that enhance or suppress E2F activity are...
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