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Article

APOE-ε4 Allele Altered the Rest-Stimulus Interactions in Healthy Middle-Aged Adults.

PloS one - 1 Jan 2015

Yan Feng-Xian, Wu Changwei W, Chao Yi-Ping, Chen Chi-Jen, Tseng Ying-Chi

Abstract excerpt

The apolipoprotein E-ε4 allele is a well-known genetic risk factor for late-onset Alzheimer's disease, which also impacts the cognitive functions and brain network connectivity in healthy middle-aged adults without dementia. Previous studies mainly focused on the effects of apolipoprotein E-ε4 allele on single index using task or resting-state fMRI. However, how these evoked and spontaneous BOLD indices interact...

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Identifiers

PMID: 26053677
DOI: 10.1371/journal.pone.0128442
PMCID: PMC4460027

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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