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Article

Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.

Journal of the American Society of Nephrology : JASN - 1 Mar 2008

Sohara Eisei, Luo Ying, Zhang Jingjing, Manning Danielle K, Beier David R, Zhou Jing

Abstract excerpt

Nek8 is a serine/threonine kinase that is mutated in the jck (juvenile cystic kidneys) mouse, a model of autosomal recessive juvenile polycystic kidney disease, but its function is poorly understood. We used the jck mouse to study the functional relationship between Nek8 and other proteins that have been implicated in polycystic kidney diseases. In the collecting tubules and collecting ducts of wild-type mice, we...

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Identifiers

PMID: 18235101
DOI: 10.1681/ASN.2006090985
PMCID: PMC2391053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.PMID 18235101Read ↗

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Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.Semantic proximity Read ↗

Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice.Semantic proximity Read ↗

A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.Semantic proximity Read ↗

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Certain heterozygous variants in the kinase domain of the serine/threonine kinase NEK8 can cause an autosomal dominant form of polycystic kidney disease.Semantic proximity Read ↗

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