Article
A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.
Development (Cambridge, England) - 1 Dec 2002
Liu Shanming, Lu Weining, Obara Tomoko, Kuida Shiei, Lehoczky Jennifer, Dewar Ken, Drummond Iain A, Beier David R
Abstract excerpt
The murine autosomal recessive juvenile cystic kidney (jck) mutation results in polycystic kidney disease. We have identified in jck mice a mutation in Nek8, a novel and highly conserved member of the Nek kinase family. In vitro expression of mutated Nek8 results in enlarged, multinucleated cells with an abnormal actin cytoskeleton. To confirm that a defect in the Nek8 gene can cause cystic disease, we performed...
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