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Article

ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning.

Nature communications - 20 Jan 2015

Czarnecki Peter G, Gabriel George C, Manning Danielle K, Sergeev Mikhail, Lemke Kristi, Klena Nikolai T, Liu Xiaoqin, Chen Yu, Li You, San Agustin Jovenal T, Garnaas Maija K, Francis Richard J, Tobita Kimimasa, Goessling Wolfram, Pazour Gregory J, Lo Cecilia W, Beier David R, Shah Jagesh V

Abstract excerpt

The ciliary kinase NEK8 plays a critical role in situs determination and cystic kidney disease, yet its exact function remains unknown. In this study, we identify ANKS6 as a target and activator of NEK8. ANKS6 requires NEK8 for localizing to the ciliary inversin compartment (IC) and activates NEK...

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Identifiers

PMID: 25599650
DOI: 10.1038/ncomms7023
PMCID: PMC4361001

Genes

NEK8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25599650-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning.PMID 25599650Read ↗

ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3.Semantic proximity Read ↗

Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.Semantic proximity Read ↗

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.Semantic proximity Read ↗

The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6.Semantic proximity Read ↗

Biallelic ANKS6 mutations cause late-onset ciliopathy with chronic kidney disease through YAP dysregulation.Semantic proximity Read ↗

Biallelic ANKS6 null variants cause notable extrarenal phenotypes in a nephronophthisis patient and lead to hepatobiliary abnormalities by YAP1 deficiency.Semantic proximity Read ↗

Disorders of left-right asymmetry: heterotaxy and situs inversus.Semantic proximity Read ↗

Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia.Semantic proximity Read ↗

Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse.Semantic proximity Read ↗

ANKS3 is mutated in a family with autosomal recessive laterality defect.Semantic proximity Read ↗

The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish.Semantic proximity Read ↗

Situs inversus in Dpcd/Poll-/-, Nme7-/- , and Pkd1l1-/- mice.Semantic proximity Read ↗

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