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Article

KRAS and BRAF mutations in 203 esophageal squamous cell carcinomas: pyrosequencing technology and literature review.

Annals of surgical oncology - 1 Dec 2013

Shigaki Hironobu, Baba Yoshifumi, Watanabe Masayuki, Miyake Keisuke, Murata Asuka, Iwagami Shiro, Ishimoto Takatsugu, Iwatsuki Masaaki, Yoshida Naoya, Baba Hideo

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) signaling is one of the most promising targets for molecular-targeted therapies in esophageal squamous cell carcinoma (ESCC). Thus, the molecular diagnosis of KRAS and BRAF mutations is clinically important in therapeutic decision making. However, the frequency of KRAS and BRAF mutations in ESCCs remains inconclusive because of the limited sample sizes of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23274581
DOI: 10.1245/s10434-012-2819-z
PMCID: PMC3853643

Genes

KRAS
BRAF
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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