Article
Endogenous aggregates of amyloidogenic cystatin C variant are removed by THP-1 cells in vitro and induce differentiation and a proinflammatory response.
Neurobiology of aging - 1 May 2013
Jonsdottir Gudrun, Ingolfsdottir Indiana Elin, Thormodsson Finnbogi R, Petersen Petur Henry
Abstract excerpt
A mutation in the human cystatin C gene leads to familial cerebral amyloid angiopathy. This disease is known as "hereditary cerebral hemorrhage with amyloidosis-Icelandic type" or "hereditary cystatin C amyloid angiopathy." The mutant cystatin C protein forms aggregates and amyloid, within the central nervous system almost exclusively in connection with the vascular system. It was not known whether immune cells...
Topics
- Cell Adhesion
- Cell Differentiation
- Cell Line, Tumor
- Cerebral Amyloid Angiopathy
- Cystatin C
- Endocytosis
- Genetic Variation
- Humans
- Inflammation
- Leukemia, Monocytic, Acute