Article
The cerebral hemorrhage-producing cystatin C variant (L68Q) in extracellular fluids.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis - 1 Mar 2001
Bjarnadottir M, Nilsson C, Lindström V, Westman A, Davidsson P, Thormodsson F, Blöndal H, Gudmundsson G, Grubb A
Abstract excerpt
A variant of the normal extracellular cysteine protease inhibitor cystatin C (L68Q-cystatin C), is the amyloid precursor in hereditary cystatin C amyloid angiopathy (HCCAA). It has been suggested that the mutation causes cellular entrapment of L68Q-cystatin C in vivo and that the variant protein is not secreted to extracellular fluids. In order to test this hypothesis, we used matrix-assisted laser desorption...
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