Article
Purification of human wild-type or variant cystatin C from conditioned media of transfected cells.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2005
Prelli Frances, Pawlik Monika, Frangione Blas, Levy Efrat
Abstract excerpt
The characterization of proteins in their native state is essential for the understanding of patho-genic isoforms. A variant of the cysteine protease inhibitor cystatin C is the major constituent of the amyloid deposited in the cerebral vasculature of patients with the Icelandic form of hereditary cerebral hemorrhage with amyloidosis (HCHWA-I). In order to study the nature of the bio-physical changes owing to the...
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