Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of cystatin C in pathophysiology of CNS diseases.

Frontiers in bioscience : a journal and virtual library - 1 May 2008

Nagai Atsushi, Terashima Masaharu, Sheikh Abdullah Md, Notsu Yoshitomo, Shimode Koichi, Yamaguchi Shuhei, Kobayashi Shotai, Kim Seung U, Masuda Junichi

Abstract excerpt

Cystatin C Leu68Gln variant is known to induce amyloid deposition in cerebral arterioles, resulting in Icelandic type cerebral amyloid angiopathy (CAA). Wild-type cystatin C is also observed in solitary CAA involving amyloid beta protein (Abeta), and accelerates the amyloidogenicity of Abeta in vitro. In neurological inflammatory diseases and leptomeningeal metastasis, low cystatin C levels are accompanied with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Amyloidosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Death

Share to Central Nervous System Diseases

Share to Cerebral Amyloid Angiopathy

Share to Cystatin C

Share to Cystatins

Share to Inflammation

Source

Identifiers

PMID: 18508448
DOI: 10.2741/2941

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of cystatin C in pathophysiology of CNS diseases.PMID 18508448Read ↗

Elevation of cystatin C in susceptible neurons in Alzheimer's disease.Semantic proximity Read ↗

Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation.Semantic proximity Read ↗

Cystatin C levels are positively correlated with both Abeta42 and tau levels in cerebrospinal fluid in persons with Alzheimer's disease, mild cognitive impairment, and healthy controls.Semantic proximity Read ↗

The Molecular Pathology of Hereditary Cystatin C Amyloid Angiopathy Causing Brain HemorrhageSemantic proximity Read ↗

Cystatin C modulates cerebral β-amyloidosisSemantic proximity Read ↗

On the role of monocytes/macrophages in the pathogenesis of central nervous system lesions in hereditary cystatin C amyloid angiopathy.Semantic proximity Read ↗

Endogenous aggregates of amyloidogenic cystatin C variant are removed by THP-1 cells in vitro and induce differentiation and a proinflammatory response.Semantic proximity Read ↗

Cystatin C mutation causing amyloid angiopathy and brain hemorrhage.Semantic proximity Read ↗

Cerebral amyloid angiopathy.Semantic proximity Read ↗

Pathological changes in basement membranes and dermal connective tissue of skin from patients with hereditary cystatin C amyloid angiopathy.Semantic proximity Read ↗

The cerebral hemorrhage-producing cystatin C variant (L68Q) in extracellular fluids.Semantic proximity Read ↗

Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.