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Article

Involvement of cystatin C in pathophysiology of CNS diseases.

Frontiers in bioscience : a journal and virtual library - 1 May 2008

Nagai Atsushi, Terashima Masaharu, Sheikh Abdullah Md, Notsu Yoshitomo, Shimode Koichi, Yamaguchi Shuhei, Kobayashi Shotai, Kim Seung U, Masuda Junichi

Abstract excerpt

Cystatin C Leu68Gln variant is known to induce amyloid deposition in cerebral arterioles, resulting in Icelandic type cerebral amyloid angiopathy (CAA). Wild-type cystatin C is also observed in solitary CAA involving amyloid beta protein (Abeta), and accelerates the amyloidogenicity of Abeta in vitro. In neurological inflammatory diseases and leptomeningeal metastasis, low cystatin C levels are accompanied with...

Topics

Amino Acid Substitution
Amyloidosis
Cell Death
Central Nervous System Diseases
Cerebral Amyloid Angiopathy
Cerebrospinal Fluid Proteins
Cystatin C
Cystatins
Genetic Variation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inflammation

Source

Identifiers

PMID: 18508448
DOI: 10.2741/2941

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