Article
Increased body temperature accelerates aggregation of the Leu-68-->Gln mutant cystatin C, the amyloid-forming protein in hereditary cystatin C amyloid angiopathy.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1994
Abrahamson M, Grubb A
Abstract excerpt
Hereditary cystatin C amyloid angiopathy is a dominantly inherited disorder, characterized by dementia, paralysis, and death from cerebral hemorrhage in early adult life. A variant of the cysteine proteinase inhibitor, cystatin C, is deposited as amyloid in the tissues of the patients and their s...
Topics
- Amino Acid Sequence
- Base Sequence
- Body Temperature
- Cerebral Amyloid Angiopathy
- Cystatins
- Escherichia coli
- Hot Temperature
- Humans
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Recombinant Proteins