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Article

Increased body temperature accelerates aggregation of the Leu-68-->Gln mutant cystatin C, the amyloid-forming protein in hereditary cystatin C amyloid angiopathy.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1994

Abrahamson M, Grubb A

Abstract excerpt

Hereditary cystatin C amyloid angiopathy is a dominantly inherited disorder, characterized by dementia, paralysis, and death from cerebral hemorrhage in early adult life. A variant of the cysteine proteinase inhibitor, cystatin C, is deposited as amyloid in the tissues of the patients and their spinal-fluid level of cystatin C is abnormally low. The disease-associated Leu-68-->Gln mutant (L68Q) cystatin C has...

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Identifiers

PMID: 8108423
DOI: 10.1073/pnas.91.4.1416
PMCID: PMC43169

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