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Article

Two stable unfolding intermediates of the disease-causing L68Q variant of human cystatin C.

Biochemistry - 8 Dec 1998

Gerhartz B, Ekiel I, Abrahamson M

Abstract excerpt

In hereditary cystatin C amyloid angiopathy (HCCAA), presence of the Leu68 --> Gln substitution in cystatin C is coupled to a decreased concentration of this major cysteine proteinase inhibitor in cerebrospinal fluid and leads to its amyloid deposition in the brain. We established a high-yield ex...

Topics

Cerebral Amyloid Angiopathy
Circular Dichroism
Cystatin C
Cystatins
Dimerization
Genetic Variation
Glutamine
Humans
Hydrogen-Ion Concentration
Leucine
Magnetic Resonance Spectroscopy
Protein Folding

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Identifiers

PMID: 9860845
DOI: 10.1021/bi980873u

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9860845-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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