Article
TIMP-1 is a novel ligand of Amyloid Precursor Protein and triggers a proinflammatory phenotype in human monocytes.
The Journal of cell biology - 6 Feb 2023
Eckfeld Celina, Schoeps Benjamin, Häußler Daniel, Frädrich Julian, Bayerl Felix, Böttcher Jan Philipp, Knolle Percy, Heisz Simone, Prokopchuk Olga, Hauner Hans, Munkhbaatar Enkhtsetseg, Demir Ihsan Ekin, Hermann Chris D, Krüger Achim
Abstract excerpt
The emerging cytokine tissue inhibitor of metalloproteinases-1 (TIMP-1) correlates with the progression of inflammatory diseases, including cancer. However, the effects of TIMP-1 on immune cell activation and underlying molecular mechanisms are largely unknown. Unbiased ligand-receptor-capture-screening revealed TIMP-1-interaction with Amyloid Precursor Protein (APP) family members, namely APP and Amyloid...
Topics
- Humans
- Amyloid beta-Protein Precursor
- Ligands
- Monocytes
- Phenotype
- Tissue Inhibitor of Metalloproteinase-1
- Inflammation
- Pancreatic Neoplasms
- Animals