Article
On the role of monocytes/macrophages in the pathogenesis of central nervous system lesions in hereditary cystatin C amyloid angiopathy.
Journal of the neurological sciences - 1 Apr 1992
Thorsteinsson L, Georgsson G, Asgeirsson B, Bjarnadóttir M, Olafsson I, Jensson O, Gudmundsson G
Abstract excerpt
The pathogenesis of the deposition of a variant cystatin C as amyloid in hereditary cystatin C amyloid angiopathy (HCCAA) is not known. To address this question the synthesis and secretion of cystatin C in cultured monocytes from 9 carriers of the mutated cystatin C gene (5 symptomatic and 4 asymptomatic) was examined. The quantity of cystatin C in cells and supernatants was determined by the ELISA method,...
Topics
- Adolescent
- Adult
- Blotting, Western
- Cells, Cultured
- Cerebral Amyloid Angiopathy
- Cerebrospinal Fluid Proteins
- Cystatin C
- Cystatins
- Female
- Genetic Variation
- Humans