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Article

Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones.

The Journal of biological chemistry - 1 Sept 2017

Constantinescu Patrick, Brown Rebecca A, Wyatt Amy R, Ranson Marie, Wilson Mark R

Abstract excerpt

The misfolding of proteins and their accumulation in extracellular tissue compartments as insoluble amyloid or amorphous protein aggregates are a hallmark feature of many debilitating protein deposition diseases such as Alzheimer's disease, prion diseases, and type II diabetes. The plasminogen activation system is best known as an extracellular fibrinolytic system but was previously reported to also be capable of...

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Identifiers

PMID: 28710283
DOI: 10.1074/jbc.M117.786657
PMCID: PMC5582837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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