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Article

Characterization of virus strains resistant to the herpes virus helicase-primase inhibitor ASP2151 (Amenamevir).

Biochemical pharmacology - 15 Aug 2012

Chono Koji, Katsumata Kiyomitsu, Kontani Toru, Shiraki Kimiyasu, Suzuki Hiroshi

Abstract excerpt

ASP2151 is an antiherpes agent targeting the helicase-primase complex of herpes simplex virus (HSV)-1, HSV-2, and varicella-zoster virus (VZV). We characterized the ASP2151-resistant HSV-1 and HSV-2 variants or mutants based on findings from sequencing analysis, growth, pathogenicity, and suscept...

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Identifiers

PMID: 22687623
DOI: 10.1016/j.bcp.2012.05.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22687623-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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