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Article

A HSV1 mutant leads to an attenuated phenotype and induces immunity with a protective effect.

PLoS pathogens - 1 Aug 2020

Xu Xingli, Feng Xiao, Wang Lichun, Yi Ting, Zheng Lichun, Jiang Guorun, Fan Shengtao, Liao Yun, Feng Min, Zhang Ying, Li Dandan, Li Qihan

Abstract excerpt

Herpes simplex virus type 1 (HSV1) is a complicated structural agent with a sophisticated transcription process and a high infection rate. A vaccine against HSV1 is urgently needed. As multiple viral-encoded proteins, including structural and nonstructural proteins, contribute to immune response stimulation, an attenuated or deficient HSV1 vaccine may be relatively reliable. Advances in genomic modification...

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Share to Herpes Simplex
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

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Source

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Identifiers

PMID: 32776994
DOI: 10.1371/journal.ppat.1008703
PMCID: PMC7440667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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