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Machine learning and genetic algorithm-guided directed evolution for the development of antimicrobial peptides

29 Feb 2024

Abstract excerpt

Antimicrobial peptides (AMPs) are valuable alternatives to traditional antibiotics, possess a variety of potent biological activities and exhibit immunomodulatory effects that alleviate difficult-to-treat infections. Clarifying the structure-activity relationships of AMPs can direct the synthesis of desirable peptide therapeutics. In this study, the lipopolysaccharide-binding domain (LBD) was identified through...

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PMID: 38431124
DOI: 10.1016/j.jare.2024.02.016

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