Article
Defensin-driven viral evolution
2020-05-09
Abstract excerpt
Enteric alpha-defensins are potent effectors of innate immunity that are abundantly expressed in the small intestine. Certain enteric bacteria and viruses are resistant to defensins and even appropriate them to enhance infection, despite neutralization of closely related microbes. We therefore hypothesized that defensins impose selective pressure during fecal-oral transmission. Upon passaging a defensin-sensitive...
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Identifiers and source
- Literature Corpus work
- 287343d4-f84b-5e84-a8f1-02b397647541
- DOI
- 10.1101/2020.05.08.079574