Article
Herpes simplex virus 1 fusion glycoprotein B H516P prefusion mutation had no effect on vaccine immunogenicity.
Vaccine - 31 May 2025
Hu Jingping, Cao Han, Luan Ning, Zhang Xiaolong, Liang Bingyan, Gao Dandan, Lei Zhentao, Bi Yanwei, Liu Cunbao
Abstract excerpt
Herpes simplex virus (HSV) is a prevalent virus worldwide that is capable of causing a range of diseases, including mucocutaneous lesions in oral and genital regions. More importantly, HSV can cause encephalitis or meningitis under rare circumstances. As a result of the complicated membrane fusion mechanism of HSV, there are still no licensed vaccines at present, although many HSV vaccines are in the clinical...
Read the complete abstract on PubMedTopics
- Animals
- Viral Envelope Proteins
- Mice, Inbred BALB C
- Mice
- Female
- Antibodies, Neutralizing