Article
PPP2R1A mutation is a rare event in ovarian carcinoma across histological subtypes.
Anticancer research - 1 Jan 2013
Rahman Munmun, Nakayama Kentaro, Rahman Mohammed Tanjimur, Nakayama Naomi, Katagiri Hiroshi, Katagiri Atsuko, Ishibashi Tomoka, Ishikawa Masako, Iida Kouji, Otsuki Yoshiro, Nakayama Satoru, Miyazaki Kohji
Abstract excerpt
Somatic mutations in PPP2R1A, which encodes a scaffolding subunit of serine/threonine protein phosphatase 2A (PP2A), have recently been described in different types of gynecological neoplasias. To extend this observation, we examined the frequency of PPP2R1A mutation in some major histological subtypes of type I and type II ovarian carcinoma. Mutational analysis of PPP2R1A (exons 5 and 6) was performed on 88...
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