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High Frequency of PIK3R1 Alterations in Ovarian Cancers: Clinicopathological and Molecular Associations

15 Jan 2025

Abstract excerpt

Background: The phosphoinositide 3-kinase (PI3K) pathway is activated in multiple cancers. However, the significance of PIK3R1 encoding the PI3K regulatory subunit, an inhibitor of the PI3K catalytic subunit encoded by PIK3CA, in ovarian cancer development is largely unknown. Methods: Here, we investigated PIK3R1 genomic alterations and gene expression by direct sequencing and qPCR methods in 197 ovarian cancers....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39858051
DOI: 10.3390/cancers17020269

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