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Article

The role of PPP2R1A variants in gynecologic malignancies: a paradigm shift in immuno-oncology.

Journal of translational medicine - 30 Apr 2026

Chen Junying, Tan Yudi, Wei Yuying, Jin Yuxuan, Huang Jingwen

Abstract excerpt

BACKGROUND: Protein Phosphatase 2 A (PP2A), a key tumor suppressor, is frequently inactivated in cancer through mutations in its scaffold-encoding gene, PPP2R1A. This is particularly common in aggressive gynecologic malignancies, specifically uterine serous carcinoma (USC) and ovarian clear cell carcinoma (OCCC). A compelling paradox has emerged: while these mutations are potent oncogenic drivers, they are also...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42063097
DOI: 10.1186/s12967-026-08181-3
PMCID: PMC13276999

Genes

PPP2R1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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