Article

Chemical exhaustion of RPA in cancer treatment

2020-12-02

Abstract excerpt

Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination and the DNA-damage response (DDR). We have developed second generation RPA inhibitors (RPAi’s) that block the RPA-DNA interaction. These DNA-binding inhibitors (DBi’s) can elicit a state of cellular RPA exhaustion resulting in single agent in vitro anticancer activity across a broad spectrum of cancers and in vivo activit...

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Literature Corpus work: 3b885f68-019a-5c09-a224-d0c82e3c0933
DOI: 10.1101/2020.11.30.404640

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