Article
Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk.
Oral oncology - 1 Sept 2011
Anantharaman Devasena, Samant Tanuja A, Sen Subrata, Mahimkar Manoj B
Abstract excerpt
The highest rates of oral squamous cell carcinomas are observed in south Asia, particularly in India, where complex forms of tobacco and alcohol exposures exist. Genetic polymorphisms contribute significantly to observed differences in cancer susceptibility. We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, , ,...