Article
High-throughput in vivo genotoxicity testing: an automated readout system for the somatic mutation and recombination test (SMART).
PloS one - 1 Jan 2015
Lombardot Benoit, Oh Chun-Taek, Kwak Jihoon, Genovesio Auguste, Kang Myungjoo, Hansen Michael Adsett Edberg, Han Sung-Jun
Abstract excerpt
Genotoxicity testing is an important component of toxicity assessment. As illustrated by the European registration, evaluation, authorization, and restriction of chemicals (REACH) directive, it concerns all the chemicals used in industry. The commonly used in vivo mammalian tests appear to be ill adapted to tackle the large compound sets involved, due to throughput, cost, and ethical issues. The somatic mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.