Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SJG-136 (NSC 694501), a Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity

15 Sept 2004

Abstract excerpt

SJG-136 (NSC 694501) is a rationally designed pyrrolobenzodiazepine dimer that binds in the minor groove of DNA. It spans 6 bp with a preference for binding to purine-GATC-pyrimidine sequences. The agent has potent activity in the National Cancer Institute (NCI) anticancer drug screen with 50% net growth inhibition conferred by 0.14 to 320 nmol/L (7.4 nmol/L mean). Sensitive cell lines exhibit total growth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Cancer Treatment and Pharmacology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15374986
DOI: 10.1158/0008-5472.can-03-2941

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SJG-136 (NSC 694501), a Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor ActivityPMID 15374986Read ↗

NSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer CellsSemantic proximity Read ↗

PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti‐tumour activitySemantic proximity Read ↗

Cytotoxic α-Halogenoacrylic Derivatives of Distamycin A and CongenersSemantic proximity Read ↗

Biological characterization of MLN944: a potent DNA binding agent.Semantic proximity Read ↗

Reply to: The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cellsSemantic proximity Read ↗

Chloroquine-induced DNA damage synergizes with DNA repair inhibitors causing cancer cell deathSemantic proximity Read ↗

Preclinical Development of the Novel Chk1 Inhibitor SCH900776 in Combination with DNA-Damaging Agents and AntimetabolitesSemantic proximity Read ↗

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.Semantic proximity Read ↗

Evolution of Nitrogen-Based Alkylating Anticancer AgentsSemantic proximity Read ↗

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.Semantic proximity Read ↗

Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition.Semantic proximity Read ↗

Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair InhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.