Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells.

doi:10.1093/mutage/ger021

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Article

Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells.

Mutagenesis - 1 Sept 2011

Magkoufopoulou C, Claessen S M H, Jennen D G J, Kleinjans J C S, van Delft J H M

Abstract excerpt

The conventional in vitro assays for genotoxicity assessment of chemicals are characterised by a high false-positive rate, thus failing to correctly predict their in vivo genotoxic effects. This study aimed to identify the cellular mechanisms induced by the false-positive genotoxins quercetin, 8-Hydroxyquinoline and 17-beta oestradiol in comparison to true genotoxins and non-genotoxins, by combining in vitro...

Topics

Cell Cycle
Cluster Analysis
DNA Damage
Gene Expression Profiling
Gene Expression Regulation
Hep G2 Cells
Humans
Molecular Sequence Annotation
Mutagenicity Tests
Mutagens
Phenotype

Source

Open in PubMed

Identifiers

PMID: 21632981
DOI: 10.1093/mutage/ger021

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