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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death

19 Mar 2012

Abstract excerpt

Human ATAD5 is a biomarker for identifying genotoxic compounds because ATAD5 protein levels increase posttranscriptionally in response to DNA damage. We screened over 4,000 compounds with a cell-based quantitative high-throughput ATAD5-luciferase assay detecting genotoxic compounds. We identified 22 antioxidants, including resveratrol, genistein, and baicalein, that are currently used or investigated for the...

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PMID: 22431602
DOI: 10.1073/pnas.1114278109

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